Screening Services Archives - Page 4 of 12

Discovery of a Specific CKIP-1 Ligand using DEL

Casein kinase 2-interacting protein-1 (CKIP-1) performs a critical negative role in the regulation of bone formation. Accumulated evidence strongly supports...

Application of Affinity Selection Mass Spectrometry: Membrane Proteins

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate...

Application of Affinity Selection Mass Spectrometry: Molecular Glues Drug Discovery

Introduction: New modalities, such as molecular glues, require robust screening strategies to identify and develop the most promising candidates efficiently....

Highly Selective Novel Heme Oxygenase-1 Hits Found by DEL

The heme oxygenase (HO) family comprises the major isozymes HO-1 and HO-2, of which HO-1 is deemed as an emerging...

Recognition of NIS1 by BRI1-Associated Receptor Kinase 1

The safe production of cultivated plants is threatened by various fungal diseases. NIS1 is a secreted effector protein produced by...

Fragment-based Drug Discovery

Fragment-based drug discovery is one of the most well-developed approaches for projects starting from small, low-affinity compounds. Powerful biophysical and...