Screening Services Archives - Page 3 of 12

Discovery of a Selective BET Inhibitor for Treating Osteoarthritis

Bromodomain and extra-terminal domain (BET) family proteins are key regulators of gene transcription and have been implicated in a wide...

Targeted Protein Degradation Platform

Targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular...

Strategies for Screening and Characterizing Targeted Covalent Inhibitors

With advancements in drug design, there is resurging interest in drugs that form covalent bonds with their targets, often referred...

Discovery of a Specific CKIP-1 Ligand using DEL

Casein kinase 2-interacting protein-1 (CKIP-1) performs a critical negative role in the regulation of bone formation. Accumulated evidence strongly supports...

Application of Affinity Selection Mass Spectrometry: Membrane Proteins

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate...

Application of Affinity Selection Mass Spectrometry: Molecular Glues Drug Discovery

Introduction: New modalities, such as molecular glues, require robust screening strategies to identify and develop the most promising candidates efficiently....

Highly Selective Novel Heme Oxygenase-1 Hits Found by DEL

The heme oxygenase (HO) family comprises the major isozymes HO-1 and HO-2, of which HO-1 is deemed as an emerging...

Recognition of NIS1 by BRI1-Associated Receptor Kinase 1

The safe production of cultivated plants is threatened by various fungal diseases. NIS1 is a secreted effector protein produced by...

Fragment-based Drug Discovery

Fragment-based drug discovery is one of the most well-developed approaches for projects starting from small, low-affinity compounds. Powerful biophysical and...

Knowledge Library