Mass Spectrometry-based Assays Archives

Influence of ssDNA or dsDNA Tags on Ligand Binding Affinity

DNA-encoded libraries have become widely used in drug discovery, and several approaches for linking chemical compounds to DNA have been...

Native Mass Spectrometry Facilitates Validation of DEL Hits

Hit validation is a crucial step in drug discovery based on DNA-encoded libraries (DEL). Rapid and accurate resynthesis of compounds,...

Accelerating CIP Discovery with ASMS and DEL

Chemical inducers of proximity (CIPs) are small molecules that induce the proximity of two biological targets, usually proteins. Molecular glues...

Application of Affinity Selection Mass Spectrometry: Membrane Proteins

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate...

Application of Affinity Selection Mass Spectrometry: Molecular Glues Drug Discovery

Introduction: New modalities, such as molecular glues, require robust screening strategies to identify and develop the most promising candidates efficiently....

Recognition of NIS1 by BRI1-Associated Receptor Kinase 1

The safe production of cultivated plants is threatened by various fungal diseases. NIS1 is a secreted effector protein produced by...

Discovery Platform for Targeted Protein Degradation

In the last decade, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific...

In Silico Drug Discovery Platform

WuXi AppTec offers a comprehensive platform of in silico drug discovery services to accelerate the process of hit finding and...

Application of ASMS for Molecular Glue Discovery

Molecular glues possess the remarkable ability to induce protein-protein interactions. In the pursuit of targeting the CDK12/CCNK/DDB1 complex, an ASMS...

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