Knowledge Library

Application of ML-enriched ASMS for Hit Discovery

GLUT1 serves as the conduit for transporting glucose from the extracellular milieu into the cell, thereby fueling cellular physiological activities via glucose metabolism. Its overexpression has been documented in various tumor cells, establishing GLUT1 as a promising therapeutic target. During an ASMS screening of GLUT1, a counter screen was introduced to effectively mitigate false positives …Read More >

Resource Type: Poster
Resource Topic: Mass Spectrometry-based Assays, Screening Libraries

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Application of ASMS for Molecular Glue Discovery

Molecular glues possess the remarkable ability to induce protein-protein interactions. In the pursuit of targeting the CDK12/CCNK/DDB1 complex, an ASMS screening strategy was employed, resulting in the successful identification of two active molecular glues from a subset of 2000 small molecules within the WuXi AppTec compound library. Validation efforts revealed compelling findings: the two small …Read More >

Resource Type: Poster
Resource Topic: Mass Spectrometry-based Assays, Screening Libraries

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Screening Methods to Identify RNA-Targeting Small Molecules

RNA molecules are promising drug targets due to their genomic prevalence, disease involvement, and druggable complex structures. Successful examples include RNA-targeting small molecule drugs for spinal muscular atrophy (SMA), with on-going efforts in other RNA-related diseases. Here, Dr. Zhifeng Yu presents our toolbox for discovering RNA-targeting small molecules, with a focus on unique DNA-encoded libraries …Read More >

Resource Type: Webinar
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Hit Finding, Mass Spectrometry-based Assays

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TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery

WuXi AppTec scientists recently contributed to a research study which utilized an affinity purification mass spectrometry approach to identify nuclear interacting partners of Transcriptional Enhanced Associate Domain (TEAD) proteins.  The authors found a significant enrichment of interacting proteins linked to DNA damage, and they showed that depletion of TEAD transcription factors makes cells more susceptible …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Biochemical Assays, Cell-based Assays, in vitro biology, Mass Spectrometry-based Assays, Oncology

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Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >

Resource Type: Presentation, Video
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Mass Spectrometry-based Assays, Oligonucleotides, Small Molecules

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Biophysical and Structural Biology Methods Enable Fragment-based Covalent Ligand Discovery of Human BTK

Drug Discovery Chemistry Conference 2023 Powerful biophysical and structural biology tools enable the study of large numbers of covalent fragments and are opening up new possibilities in the treatment of various diseases. Here, Dr. Moran Jerabek-Willemsen, Head of Biophysics & Screening in WuXi Biology reports the results of a covalent FBDD project on Bruton’s Tyrosine …Read More >

Resource Type: Presentation, Video
Resource Topic: Biochemical Assays, Biophysical Assays, Discovery Chemistry, Fragment-Based Drug Discovery, Hit-to-Lead, Lead Optimization, Mass Spectrometry-based Assays, Screening Libraries, Small Molecules, Structural Biology

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Crystal-Grade Protein Production

With a focus on quality and stability, gain access to our established systems, strategies, and advanced co-expression vectors to address even the most significant challenges of recombinant protein production.

Resource Type: Brochure
Resource Topic: Biophysical Assays, Mass Spectrometry-based Assays, Structural Biology, Target Identification and Validation

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Targeted Protein Degradation

WuXi AppTec utilizes state-of-the-art techniques to support drug discovery teams focused on targeted protein degradation. Our services include a broad range of ligand-finding methods, such as DEL, fragment screening, ASMS, and virtual screening. We provide custom linker design and complex synthesis for new linkers and E3 ligase ligands. To support lead optimization efforts, our platform …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Cell-based Assays, Mass Spectrometry-based Assays, Small Molecules, Structural Biology, Targeted Protein Degradation

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Drugging the Undruggable: Leveraging the Right Screening Methods for Challenging Targets

Challenging targets, such as membrane proteins or protein-protein interactions were considered undruggable in the past. However, today a variety of screening methods can be used to help develop drugs against these formerly undruggable targets.

Resource Type: Infographic
Resource Topic: DNA-Encoded Library (DEL), Hit Finding, in silico services, Mass Spectrometry-based Assays, Screening Services, Small Molecules, Structural Biology, Target Identification and Validation, Targeted Protein Degradation

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Resource Topics
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