in vivo Pharmacology Archives - Page 2 of 20

Radionuclide Drug Conjugates in Anticancer Treatment

Mechanisms, Recent Progress, and Animal Models Radionuclide drug conjugates (RDCs), a novel class of precision tumor-targeting therapeutic and diagnostic agents,...

Shortened Cardio-Metabolic Mouse Model of HFpEF

Current preclinical murine models of heart failure with preserved ejection fraction (HFpEF) require prolonged modeling periods, posing significant challenges for...

Efficacy of a TL1A Antibody in an Acute Colitis Mouse Model

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

GLP1R and GIPR Dual-Target Drugs in Humanized GIPR Mice

Multi-target drugs targeting GLP1R/GIPR/GCGR have demonstrated superior efficacy for weight loss and glycemic control compared to single-target GLP1R drugs. However,...

DLL3‑related Tumor Models in Humanized Mice

OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as well...

Efficacy of a Cell Therapy Drug on Kainic Acid-Induced Seizures

Epilepsy is one of the most common neurological disorders, and cell therapy is a promising area of research that has...

Efficacy of Xanomeline on Cognitive Dysfunction

Psychotropic drug abuse, particularly involving amphetamines and ketamine, has been shown to induce alterations in dopaminergic innervation, neuronal structure, and...

Induced Pruritus Model in NHP

The “itch-scratch cycle” is a central pathogenic driver in many pruritic (itch-related) inflammatory skin diseases, such as atopic dermatitis (AD),...

Spontaneous Mouse Tumor-derived Syngeneic Models

Spontaneous mouse tumor-derived syngeneic models are valuable tools in preclinical cancer research. These tumor models offer unique advantages because immunotherapies...

Knowledge Library