Cardiovascular & Metabolic Diseases Archives

Shortened Cardio-Metabolic Mouse Model of HFpEF

Current preclinical murine models of heart failure with preserved ejection fraction (HFpEF) require prolonged modeling periods, posing significant challenges for...

International Women’s Day: Safeguarding Women’s Health Across the Lifespan with the Power of Science

Introduction In recognition of International Women’s Day, we spotlight women’s health—a continuously evolving global healthcare issue. The year 2025 marks...

Women’s Health: Innovative Medications for Menopause

Introduction: Women spend about one-third of their lives in menopause or post-menopause, a period that marks the gradual decline of...

Cardiac Manifestations of Fabry Disease

Lysosomal storage disorders are rare genetic conditions that cause a buildup of toxic materials in the cells of various organs....

Dianthus Platform: Screening for CRBN-DDB1 Proteolysis-Targeting Chimeras and Molecular Glues

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of...

Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies

Animal studies may provide a close approximation to humans when addressing the key challenge of clinical translatability. In the preclinical...

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α

WuXi AppTec scientists recently contributed to a research article in the Journal of Medicinal Chemistry describing the optimization of a...

Large-scale synthesis of a Notum inhibitor employing a modified Sakai reaction as the key step

WuXi AppTec scientists recently contributed to a research article in the Royal Society of Chemistry describing the large-scale synthesis of...

Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization,...

Knowledge Library