Knowledge Library

How Does It Work? | Targeted Protein Degrader

As part of our dedication to providing an #openaccess platform, so our entire ecosystem can come together to share #science & #collaborate to better the lives of all #patientsfirst. We’ve created MoA animations in our new series exploring biotech topics on a molecular level. First up, we explain the intricacies of how targeted protein degradation …Read More >
Resource Type: Video
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Oncology Target Identification and Validation Targeted Protein Degradation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding in vitro biology Phenotypic Assays Screening Libraries Small Molecules Target Identification and Validation

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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HIJACKING CELLULAR MECHANISMS TO TREAT COMPLEX DISEASES
Resource Type: White Paper
Resource Topic: Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays DRUG DISCOVERY AND INNOVATION in vitro biology Oligonucleotides Oncology Rare Diseases Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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Optimizing Drug Pipelines With Biophysical Methods

Download our whitepaper on how using biophysical techniques can enhance and streamline processes throughout the drug discovery and validation cycle. Discover fresh opportunities to characterize challenging drug targets, examine biophysical screening methods, and look toward what’s next for biophysical methods in drug discovery.
Resource Type: White Paper
Resource Topic: Biochemical Assays Biophysical Assays Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays

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Structure determination: comparison of methods

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.
Resource Type: Brochure Infographic
Resource Topic: Biophysical Assays Cells and Protein Science Hit Finding Hit-to-Lead Lead Optimization Structural Biology Target Identification and Validation

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WuXi Discovery Services Newsletter: November 2021
Resource Type: Newsletter
Resource Topic: Biophysical Assays Central Nervous System & Pain Oligonucleotides Rare Diseases Targeted Protein Degradation

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One-Stop Target-to-Hit Solutions

WuXi AppTec  | Target-to-Hit Solutions Protein Production  | All Target Classes and Challenging Proteins Biophysical & Biochemical Platforms |  Ready-To-Go Assay for Broad Range of Drug Targets Structural Biology Platforms Fragment Library & Screening ~3100 “Rule of three” compliant fragments
Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Chemical Biology and Proteomics Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation

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