Knowledge Library

Regenerable Surface Plasmon Resonance (SPR) Surfaces for Reliable, Cost-Effective, and Wide-Ranging Applications

Traditional SPR-based drug discovery efforts in the small-molecule space have revolved around single-use chips for screening and hit-to-lead efforts. Inspired by recent technological advances, we have established simple regenerable protocols that can (1) accommodate target-proteins with common tags such as His- and Avi-, (2) reach sufficient surface density for small-molecule testing, and (3) maintain a …Read More >

Resource Type: Latest Science Poster
Resource Topic: Biophysical Assays

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Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >

Resource Type: Presentation Video
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oligonucleotides Small Molecules

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Biophysical and Structural Biology Methods Enable Fragment-based Covalent Ligand Discovery of Human BTK

Drug Discovery Chemistry Conference 2023 Powerful biophysical and structural biology tools enable the study of large numbers of covalent fragments and are opening up new possibilities in the treatment of various diseases. Here, Dr. Moran Jerabek-Willemsen, Head of Biophysics & Screening in WuXi Biology reports the results of a covalent FBDD project on Bruton’s Tyrosine …Read More >

Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Discovery Chemistry Fragment-Based Drug Discovery Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology

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PRMT5-WDR77 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Lead Optimization Structural Biology

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PIK3alpha Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Lead Optimization Structural Biology

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NLRP3 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Structural Biology

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KRAS Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Hit-to-Lead Lead Optimization Structural Biology

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XPRESS Portfolio: Off-the-Shelf Crystallography

Resource Type: Brochure
Resource Topic: Biophysical Assays Structural Biology

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DDC 2023: Biophysical & Functional Characterization of Bifunctional Small Molecules Enables TPD Drug Discovery

Leverage our platform of biophysical methods to accelerate your research on targeted protein degradation. At DDC 2023, WuXi AppTec scientists presented an in-depth panel of assays to support the characterization of bifunctional small molecules. Our cutting-edge services include target protein ubiquitination and degradation assays, techniques to evaluate binary binding, and proximity assays to measure ternary …Read More >

Resource Type: Latest Science Poster
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Hit-to-Lead Lead Optimization Small Molecules Structural Biology Targeted Protein Degradation

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