Knowledge Library

Emerging Modalities in Drug Discovery

In this webinar, we present the latest advances and challenges facing researchers focused on new and emerging modalities in drug discovery. Topics include targeted protein degradation, targeted covalent inhibitors, and nucleic acid therapeutics. Our expert speaker, Dr. Tao Guo, discusses solutions for addressing the complexities in designing, synthesizing, and optimizing these molecules, with an added …Read More >

Resource Type: Latest Science, Webinar
Resource Topic: Discovery Chemistry, Oligonucleotides, Small Molecules, Targeted Protein Degradation

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Recent Advances in Library Synthesis to Accelerate Medicinal Chemistry Research

Learn how parallel medicinal chemistry (PMC) and high throughput experimentation (HTE) combined with machine learning can provide a more focused approach to target molecules, resulting in a more concentrated set of compounds to make the process of lead selection easier. Our experts show how PMC can shorten the turnaround time of the design-synthesis-test cycle, providing …Read More >

Resource Type: Webinar
Resource Topic: Discovery Chemistry, Hit Finding, Hit-to-Lead, Small Molecules

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Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases, Biophysical Assays, Cardiovascular & Metabolic Diseases, Central Nervous System & Pain, Discovery Chemistry, DNA-Encoded Library (DEL), Hit Finding, Hit-to-Lead, Lead Optimization, Oncology, Small Molecules, Structural Biology, Target-Specific Assays, Targeted Protein Degradation

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Biological Characterization and Development Workflows for Targeted Protein Degradation

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases, Biochemical Assays, Cardiovascular & Metabolic Diseases, Cell-based Assays, Central Nervous System & Pain, Hit-to-Lead, in vitro biology, in vivo Pharmacology, Lead Optimization, Oncology, Small Molecules, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation

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Introduction into Fragment Based Drug Discovery

Fragment-based drug discovery (FBDD) is a method used for finding hit compounds as one strategy of hit identification in the drug discovery process. Fragments are small molecules with a low molecular weight, smaller than lead molecules or druglike molecules. The FBDD technology is based on identifying small chemical fragments, which bind to the biological target …Read More >

Resource Type: Latest Science, Webinar
Resource Topic: Discovery Chemistry, Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Screening Libraries, Small Molecules, Target Identification and Validation

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Oligonucleotide Drug Development (CMC)

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. During this webinar …Read More >

Resource Type: Webinar
Resource Topic: Candidate Selection, Oligonucleotides

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Oligonucleotide Drug Discovery

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. In this webinar, …Read More >

Resource Type: Webinar
Resource Topic: Biochemical Assays, Cell-based Assays, Discovery Chemistry, Hit-to-Lead, in vitro biology, in vivo Pharmacology, Lead Optimization, Oligonucleotides, Safety and Early Toxicity

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability

Resource Type: Webinar
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Screening Libraries, Small Molecules, Target Identification and Validation, Target-Specific Assays

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Self Service DNA Encoded Library Screening

Resource Type: Webinar
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Hit Finding, Small Molecules, Target Identification and Validation

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Resource Topics
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