Knowledge Library

In Vitro Immunology Assay Platform

Leverage our panel of in vitro immunology assays to accelerate your lead optimization efforts.  WuXi AppTec offers a comprehensive platform of immune profiling services, including ligand/receptor binding for target validation and cell-based functional assays to characterize both innate and adaptive immune responses. Our end-to-end services panel includes suppressive assays, mixed lymphocyte reactions, mast cell degranulation assays, …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Immunology Lead Optimization

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Evaluation Platform for Bispecific Antibodies

WuXi AppTec offers a full range of services to characterize bispecific antibodies and bispecific T cell engagers (BiTEs).  Our comprehensive platform includes cell line selection and target expression, assessment of binding affinity (SPR, flow cytometry), in vitro activity testing (T cell activation, cytokine release, cytotoxicity), and evaluation of in vivo efficacy (using HSC and PBMC …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Oncology Tumor Models

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Lysosomal Storage Disease Mouse Models

Lysosomal storage disorders (LSDs) are rare genetic conditions that cause a buildup of toxic materials in the cells of various organs.  As part of our rare disease models platform, WuXi AppTec offers an extensive panel of LSD mouse models, including Gaucher disease, Pompe disease, Fabry disease, and Hurler syndrome (MPS I).  Our service platform supports …Read More >

Resource Type: Latest Science Presentation
Resource Topic: in vivo Pharmacology Rare Diseases

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CD34+ Hematopoietic Stem Cell Differentiation Platform

To accelerate screening and lead optimization efforts involving immune cell differentiation, WuXi AppTec offers a comprehensive CD34+ hematopoietic stem cell differentiation platform.  Our panel includes neutrophil, eosinophil, erythroid, and mast cell differentiation, as well as monocyte/macrophage differentiation and polarization, and megakaryocyte/platelet differentiation. Check out our comprehensive platform of immune profiling and biomarker services

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Hit-to-Lead Immunology

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Enzalutamide-resistant LNCaP ARF877L Mutation KI model

We have established an enzalutamide-resistant (LNCaP AR-F877L mutation) KI prostate cancer model to support the development of next-generation therapeutics.  An LNCaP AR-F877L KI cell line was shown to be resistant to enzalutamide, and in vivo animal validation studies demonstrated that enzalutamide was not efficacious to prevent tumor growth using this drug-resistant model. Check out our …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

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Gout Models

As part of our autoimmune and inflammatory disease platform, we provide an extensive panel of monosodium urate (MSU) induced gout models, including: Air pouch gout models in mice and rats Articular injection induced gout models in mice, rats and rabbits View our wide range of in vitro assays and in vivo animal models related to inflammation …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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Single-cell RNA Sequencing Services

Pilot Studies (selection of optimal time points and dosing) In vivo treatment Sample collection (from complex tissue to single cell isolation) Library preparation and sequencing Bioinformatics analysis View our cutting-edge immune profiling and biomarker platforms

Resource Type: Latest Science Presentation
Resource Topic: Biomarkers Cell-based Assays

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Inflammatory Bowel Disease Models

We offer an extensive panel of inflammatory bowel disease models in mice and rats, including genetically modified, chemically induced, and adoptive transfer-related IBD models. Let our experts help you choose the best IBD animal models to advance your research programs. Learn more about our platform of inflammation models  

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Hit-to-Lead in vivo Pharmacology Lead Optimization

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Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >

Resource Type: Presentation Video
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oligonucleotides Small Molecules

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