Case Study: Clinically Relevant NASH Animal Model
In this case study, we demonstrate clinical relevance of the HFD+CCL4 (high-fat diet and carbon tetrachloride) NASH animal model. Improvement...
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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)
WuXi AppTec scientists contributed to a study which identified a novel, indole-based, selective estrogen receptor degrader (SERD), designated LX-039. The authors...
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DELs enable the development of BRET probes for target engagement studies in cells
WuXi AppTec scientists recently contributed to a research article in Cell Chemical Biology demonstrating the successful conversion of ligands identified...
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In Vitro Immunology Assay Platform
Leverage our panel of in vitro immunology assays to accelerate your lead optimization efforts. WuXi AppTec offers a comprehensive platform of...
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Evaluation Platform for Bispecific Antibodies
WuXi AppTec offers a full range of services to characterize bispecific antibodies and bispecific T cell engagers (BiTEs). Our comprehensive...
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Lysosomal Storage Disease Mouse Models
Lysosomal storage disorders (LSDs) are rare genetic conditions that cause a buildup of toxic materials in the cells of various...
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CD34+ Hematopoietic Stem Cell Differentiation Platform
To accelerate screening and lead optimization efforts involving immune cell differentiation, WuXi AppTec offers a comprehensive CD34+ hematopoietic stem cell...
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Inhibition of the hERG potassium ion channel by non-nucleoside CMV polymerase antiviral inhibitors
WuXi AppTec scientists collaborated on a study to characterize a series of pyrroloquinoline derivatives that were designed and synthesized to...
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TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery
WuXi AppTec scientists recently contributed to a research study which utilized an affinity purification mass spectrometry approach to identify nuclear...
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