Resources Archive - Page 12 of 46

Fibroblast Growth Factor Receptors

Fibroblast growth factor receptor (FGFR) signaling pathways represent promising targets for therapeutics owing to their role in development, tissue, and...

Novel DEL Hit That Binds in the Cbl-b SH2 Domain

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, is a key regulator of T cell activation and plays...

OncoWuXi Express: Comprehensive PDX Panel Service for Drug Discovery

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well...

Research Strategies for the Discovery of Targeted Protein Degraders

In this webinar, experts present research strategies for the discovery of targeted protein degraders. Over the past decade, targeted protein degradation...

Cardiac Manifestations of Fabry Disease

Lysosomal storage disorders are rare genetic conditions that cause a buildup of toxic materials in the cells of various organs....

Pharmacodynamic and Pharmacokinetic Profile of a Novel GLP-1 Receptor Biased Agonist

Glucagon‐like peptide‐1 (GLP-1) receptor agonists have emerged as promising therapeutic options for addressing type‐2 diabetes, obesity, and related conditions. However,...

OncoWuXi Express: Efficacy of JAK Inhibitors in a Type II Collagen-induced Arthritis Model

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as...

USP7 Inhibitors Reveal a Differentiated Mechanism of p53-Driven Anti-Cancer Activity

Ubiquitin-speciﬁc protease 7 (USP7) is a deubiquitinating enzyme that cleaves ubiquitin from a range of substrates, shielding them from degradation...

Preclinical Evaluation of the SARS-CoV-2 Mpro Inhibitor RAY1216

WuXi AppTec scientists contributed to a research article in the journal Nature Microbiology, which characterized a peptidomimetic inhibitor of the...

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