Emerging Drug Discovery Strategies for Targeted Protein Degradation

In the last decade, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms.  In our latest White Paper, “Emerging Drug Discovery Strategies for Targeted Protein Degradation” we explore how DNA-encoded library (DEL) technology can be used for direct discovery of proteolysis-targeting chimeras and to identify ligands intended for development of bifunctional molecules.  We also discuss linker optimization, biological characterization, DMPK optimization, and formulation strategies.

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White Paper_Targeted Protein Degradation

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