Leveraging Precocious Puberty Animal Models for Preclinical Research Precocious puberty, one of the frequently observed conditions in pediatric endocrinology, significantly impacts the physiological, psychological, and long-term health of children. Moreover, this disorder is associated with increased risks of various diseases [1]. Precocious puberty is an endocrine disorder caused by abnormal secretion of sex hormones. It …Read More >

Sequence design and chemical synthesis In vitro evaluation of stability and efficacy Cell lines 1500+ cell lines and patient-derived fibroblasts Customized stable cell lines available Primary cells Primary hepatocytes of human, mouse, rat, dog and monkey Customized primary cells available Reporter cell lines ASO splicing reporter psiCHECK Methods Free uptake Transfection Additional services include: Stability …Read More >

Design and production of mRNA Design and optimization of mRNA sequences Utilizing the design and optimization techniques for mRNA sequences, UTR screening, and codon optimization Plasmid and DNA template productions for in vitro transcription Employment of a classical three-step purification method Implementation of mono-enzyme digestion and purification through chromatography Research scale mRNA production and characterization …Read More >

Capacity Comprehensive virus, bacteria, fungi coverages Supporting drug and vaccine discovery from early research to clinical trials Capability 20+ various viruses Supporting discovery of antivirals and vaccines, including HBV, SARS-CoV, IFV, RSV, HCV, HIV, EV71, herpes, rabies, and other viruses 130+ different bacterial and fungal species Supporting discovery of antibacterial and antifungal therapeutics, including ESKAPE, …Read More >

Hepatobiliary Disease Platform All-encompassing hepatobiliary disease models: NAFLD, NASH, Fibrosis, Cirrhosis, PBC/PSC, ALD, and more Comprehensive hepatic tissue bank and transcriptomics database Professional quantitative analysis in pathology Histopathology Laboratory CAP-certified pathology laboratory Tissue processor Embedding center Cyostats Microtomes Staining workstation IHC & ISH stainer Laser-scanning confocal microscope HALO-AI quantitative histopathology

Expanded Role of PDX Models in Anticancer Drug Development Patient-derived xenograft (PDX) models are established by implanting surgically resected patient tumor tissues into immunodeficient mice and have become a pivotal tool in preclinical cancer research due to high clinical-relevance. These models faithfully preserve the original tumor’s molecular, histopathological and pharmacological characteristics, reflecting the heterogeneity and …Read More >

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At IMMUNOLOGY2024, WuXi AppTec presented a poster highlighting the development of multiple preclinical …Read More >

Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that is characterized by recurrent eczematous lesions. Janus kinase (JAK) inhibitors have been found to be efficacious in treating AD, although their mechanism of action in AD is not fully understood. To support preclinical research in this area, WuXi AppTec presented a poster at IMMUNOLOGY2024 …Read More >

Passive Heymann nephritis, induced by intravenous injection of anti-Fx1A in susceptible rat strains, is a complement-dependent model of glomerular disease that resembles membranous nephropathy in humans.  At IMMUNOLOGY2024, WuXi AppTec presented a poster demonstrating that rapamycin exerts a protective effect against anti-Fx1A-induced passive Heymann nephritis by reducing proteinuria.  The authors show that this antiproteinuric effect …Read More >