Oncology Archives - Page 4 of 21

Overcoming PARP Inhibitor Resistance in an Olaparib-Induced Model

Poly (ADP-ribose) polymerase inhibitors (PARPi) have emerged as a promising therapeutic approach in the treatment of various cancers, particularly those...

Novel ROR1 Antibody with High Specificity and Sensitivity for Predictive Biomarker Detection

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key mediator of non-canonical Wnt signaling and plays a critical role...

Development of NK Humanized Mouse Models

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research...

Isogeneic Trop-2 Model for Evaluating Anti-Trop-2 ADCs

Antibody-Drug Conjugates (ADCs) have made significant advancements in cancer treatment, particularly for solid tumors. The bystander effect of ADCs, where...

HPV18-Related Cancer Model Development

Cancers, like cervical cancer and head & neck cancer, are strongly linked to human papillomavirus (HPV) infection. Targeting the HPV...

Development of Novel ADC-Resistant Models

Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer...