Knowledge Library

In Silico Drug Discovery Platform

WuXi AppTec offers a comprehensive platform of in silico drug discovery services to accelerate the process of hit finding and hit-to-lead optimization.  We provide access to virtual chemical spaces built from our library of novel drug-like scaffolds, to support virtual screening and structure-based virtual screening (SBVS). Advances in ML-empowered virtual screening allows project teams to …Read More >
Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL), High-throughput screening (HTS), Hit Finding, Hit-to-Lead, in silico services, Mass Spectrometry-based Assays, Screening Libraries

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Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders.  WuXi AppTec scientists recently contributed to a study which led to the identification, optimization, and characterization of a highly potent, novel mGluR7 allosteric agonist, designated CVN636.  The authors show that CVN636 has high selectivity toward mGluR7, …Read More >
Resource Type: Latest Science, Publication
Resource Topic: Biochemical Assays, Central Nervous System & Pain, High-throughput screening (HTS), Hit Finding, Hit-to-Lead, Lead Optimization, Small Molecules

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platforms.  
Resource Type: Brochure
Resource Topic: Antibodies, Antibody Drug Conjugate, Autoimmune and Inflammatory Diseases, Biochemical Assays, Biomarkers, Biophysical Assays, Candidate Selection, CAR-T Cell, Cardiovascular & Metabolic Diseases, Cell Therapies, Cell-based Assays, Cells and Protein Science, Central Nervous System & Pain, Chemical Biology and Proteomics, Dermatology, Discovery Chemistry, DNA-Encoded Library (DEL), DRUG DISCOVERY AND INNOVATION, Fragment-Based Drug Discovery, Gene Therapies, High-throughput screening (HTS), Hit Finding, Hit-to-Lead, Immunology, in silico services, in vitro biology, in vivo Pharmacology, in vivo Toxicology, Infectious Diseases, Lead Optimization, Liver Diseases, Mass Spectrometry-based Assays, Metabolic Diseases, NASH, Oligonucleotides, Oncology, Oncolytic Viruses, Ophthalmology, Phenotypic Assays, Quantum Mechanics, Rare Diseases, Respiratory Diseases, Safety and Early Toxicity, Screening Libraries, Screening Services, Small Molecules, Structural Biology, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation, TECHNOLOGY PLATFORMS, THERAPEUTIC AREAS, THERAPEUTIC MODALITIES, Tumor Models

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Enabling Drug Discovery with Diverse Lead Generation Platforms
Resource Type: Webinar
Resource Topic: Discovery Chemistry, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, High-throughput screening (HTS), Hit Finding, Hit-to-Lead, in silico services, Lead Optimization, Mass Spectrometry-based Assays, Screening Libraries, Screening Services, Small Molecules, Structural Biology, Target Identification and Validation

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The Synthesis of an Entrepreneur: Merging a Passion for Biochemistry, Synthetic Chemistry, and Bioactive Molecules in Academia

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) Synthetic chemist Joseph Ready believes a huge amount of innovation in the drug industry comes from academia. Academic science is arguably the greatest source of innovation in our ecosystem, yet faces challenges when considering the transition from the lab to early stage …Read More >
Resource Type: Article
Resource Topic: Central Nervous System & Pain, Chemical Biology and Proteomics, Discovery Chemistry, High-throughput screening (HTS), Hit-to-Lead, Infectious Diseases, Lead Optimization, Oncology, Small Molecules, Target Identification and Validation

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >
Resource Type: Brochure
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Chemical Biology and Proteomics, Gene Therapies, High-throughput screening (HTS), Hit-to-Lead, Immunology, in vitro biology, in vivo Pharmacology, Lead Optimization, Oncology, Screening Libraries, Small Molecules, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation, Tumor Models

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