Knowledge Library

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders.  WuXi AppTec scientists recently contributed to a study which led to the identification, optimization, and characterization of a highly potent, novel mGluR7 allosteric agonist, designated CVN636.  The authors show that CVN636 has high selectivity toward mGluR7, …Read More >
Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays Central Nervous System & Pain High-throughput screening (HTS) Hit Finding Hit-to-Lead Lead Optimization Small Molecules

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platforms.  
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Enabling Drug Discovery with Diverse Lead Generation Platforms
Resource Type: Webinar
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery High-throughput screening (HTS) Hit Finding Hit-to-Lead in silico services Lead Optimization Mass Spectrometry-based Assays Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation

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The Synthesis of an Entrepreneur: Merging a Passion for Biochemistry, Synthetic Chemistry, and Bioactive Molecules in Academia

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) Synthetic chemist Joseph Ready believes a huge amount of innovation in the drug industry comes from academia. Academic science is arguably the greatest source of innovation in our ecosystem, yet faces challenges when considering the transition from the lab to early stage …Read More >
Resource Type: Article
Resource Topic: Central Nervous System & Pain Chemical Biology and Proteomics Discovery Chemistry High-throughput screening (HTS) Hit-to-Lead Infectious Diseases Lead Optimization Oncology Small Molecules Target Identification and Validation

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >
Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Clinical Bioanalysis CRISPR/Cas9 Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit-to-Lead Immunology in vitro biology in vivo Pharmacology Lead Optimization Oncology Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays Targeted Protein Degradation Tumor Models

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