DNA-Encoded Library (DEL) Archives

Screening Strategies for Molecular Glue Discovery

Molecular glues are molecules that can encourage two proteins to interact when they otherwise may not. As a consequence, they...

Webinar: Target Deconvolution and Tractability Assessment

Target deconvolution, particularly when paired with proteomics techniques, plays a crucial role in drug discovery and target identification. By using...

Influence of ssDNA or dsDNA Tags on Ligand Binding Affinity

DNA-encoded libraries have become widely used in drug discovery, and several approaches for linking chemical compounds to DNA have been...

Innovative Technologies in Early Drug Discovery

In this webinar, WuXi AppTec scientists discuss the latest innovative technologies and products in early-stage drug discovery. Viewers will gain...

Design, Synthesis & Screening of Natural Product DEL

DNA-encoded library (DEL) technology has been recognized as a major screening method, offering unique advantages through its ability to provide...

Application of On-bead DEL Technology in Target Protein Degradation Phenotypic Screen

DNA-encoded library (DEL) technology has been recognized as a major screening method, offering unique advantages through its ability to provide...

DELvision: A Protein-DEL Interaction Database

Currently, there is a lack of efficient experimental strategies to collect high-quality proteome-level data for protein-ligand interactions (PLIs). At DEL...

Integrated Screening and Assay Capabilities Facilitate Peptide Drug Discovery

Peptide-based therapeutics have emerged as a significant class of drugs in the pharmaceutical landscape, offering numerous advantages, including high specificity,...

Native Mass Spectrometry Facilitates Validation of DEL Hits

Hit validation is a crucial step in drug discovery based on DNA-encoded libraries (DEL). Rapid and accurate resynthesis of compounds,...

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