Knowledge Library

International Women’s Day: Safeguarding Women’s Health Across the Lifespan with the Power of Science

Introduction In recognition of International Women’s Day, we spotlight women’s health—a continuously evolving global healthcare issue. The year 2025 marks the 30th anniversary of the United Nations Fourth World Conference on Women, where the landmark Beijing Declaration was adopted. This pivotal document systematically outlined an action framework for advocating women’s rights, with a particular emphasis …Read More >

Resource Type: Article, Blog
Resource Topic: Autoimmune and Inflammatory Diseases, Cardiovascular & Metabolic Diseases, in vivo Pharmacology

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Women’s Health: Innovative Medications for Menopause

Introduction: Women spend about one-third of their lives in menopause or post-menopause, a period that marks the gradual decline of their reproductive capabilities [1, 2]. Menopause typically begins between the ages of 45 and 55 and is marked by 12 consecutive months without menstruation. Menopausal syndrome refers to a series of physiological and psychological symptoms …Read More >

Resource Type: Article, Blog
Resource Topic: Autoimmune and Inflammatory Diseases, Cardiovascular & Metabolic Diseases, in vivo Pharmacology

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Cardiac Manifestations of Fabry Disease

Lysosomal storage disorders are rare genetic conditions that cause a buildup of toxic materials in the cells of various organs. Fabry disease (FD) is an X-linked disorder of glycosphingolipid metabolism caused by mutations in the GLA gene encoding alpha-galactosidase A. Manifestations of FD include life-threatening renal, cardiovascular, and cerebrovascular dysfunctions. Current treatments can preserve kidney …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Cardiovascular & Metabolic Diseases, Rare Diseases

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Dianthus Platform: Screening for CRBN-DDB1 Proteolysis-Targeting Chimeras and Molecular Glues

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of this complex for the recognition and binding of proteins targeted for ubiquitination and proteasomal degradation.  To support the discovery of CRBN-DDB1 proteolysis-targeting chimeras and molecular glues, WuXi AppTec offers an integrated platform of ready-to-go assays …Read More >

Resource Type: Brochure
Resource Topic: Biophysical Assays, Cardiovascular & Metabolic Diseases, Central Nervous System & Pain, Hit Finding, Hit-to-Lead, Immunology, Infectious Diseases, Oncology

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Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies

Animal studies may provide a close approximation to humans when addressing the key challenge of clinical translatability. In the preclinical setting, new insights into disease models and mechanisms are crucial to efficacy studies. In this webinar, Dr. Deming Xu, Chief Pharmacologist, Executive Director, and Head of In Vivo Pharmacology of WuXi AppTec Discovery Biology will …Read More >

Resource Type: Webinar
Resource Topic: Cardiovascular & Metabolic Diseases, Central Nervous System & Pain, in vivo Pharmacology, Metabolic Diseases, NASH, Oligonucleotides

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Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α

WuXi AppTec scientists recently contributed to a research article in the Journal of Medicinal Chemistry describing the optimization of a piperidine series of small molecules as novel allosteric activators of PKG1α (a compelling drug target for treatment of cardiovascular diseases).  This study reveals a mechanism of action for these compounds consistent with cGMP-induced activation, including …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Cardiovascular & Metabolic Diseases, Discovery Chemistry, Small Molecules

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Large-scale synthesis of a Notum inhibitor employing a modified Sakai reaction as the key step

WuXi AppTec scientists recently contributed to a research article in the Royal Society of Chemistry describing the large-scale synthesis of a potent and selective inhibitor of Notum carboxylesterase (an enzyme that suppresses Wnt signaling pathways).  By employing a modified Sakai reaction as the key step, a one-pot synthesis of this Notum inhibitor was developed, enabling …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Cardiovascular & Metabolic Diseases, Discovery Chemistry, Liver Diseases, Oncology, Respiratory Diseases, Small Molecules

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Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases, Biophysical Assays, Cardiovascular & Metabolic Diseases, Central Nervous System & Pain, Discovery Chemistry, DNA-Encoded Library (DEL), Hit Finding, Hit-to-Lead, Lead Optimization, Oncology, Small Molecules, Structural Biology, Target-Specific Assays, Targeted Protein Degradation

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Biological Characterization and Development Workflows for Targeted Protein Degradation

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases, Biochemical Assays, Cardiovascular & Metabolic Diseases, Cell-based Assays, Central Nervous System & Pain, Hit-to-Lead, in vitro biology, in vivo Pharmacology, Lead Optimization, Oncology, Small Molecules, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation

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Resource Topics
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