Publication Archives - WuXi Biology

CTHRC1 as a Novel Candidate for Neurodevelopmental Disorders

Cognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. Due to the complexity...

mTOR Inhibition Enhances Targeted Protein Degradation Efficacy

Targeted protein degradation (TPD) approaches, including molecular glue degraders (MGDs) and proteolysis targeting chimeras (PROTACs), can overcome traditional occupancy-based inhibitor...

ALDH1A2 Inhibition Enhances Antitumor DC Vaccine Efficacy

Strategies to stimulate dendritic cell (DC) activity, such as ex vivo generation and priming of DC vaccines, have been explored...

Influence of ssDNA or dsDNA Tags on Ligand Binding Affinity

DNA-encoded libraries have become widely used in drug discovery, and several approaches for linking chemical compounds to DNA have been...

An Effective System for Senescence Modulating Drug Development

Cellular senescence plays a crucial role in aging and age-related diseases, making its study essential for the development of new...

Native Mass Spectrometry Facilitates Validation of DEL Hits

Hit validation is a crucial step in drug discovery based on DNA-encoded libraries (DEL). Rapid and accurate resynthesis of compounds,...

Discovery of a Novel CD39 Inhibitor by DEL Screening

The ATP-adenosine pathway plays a crucial role in regulating immune responses, including those involved in combating tumors. CD39 is an...

Developing Animal Gout Models

Gout is a common type of inflammatory arthritis caused by elevated uric acid levels in the blood. When uric acid...

DNA-Compatible Huisgen Cycloaddition

In our latest publication, WuXi AppTec scientists introduce two new methods that utilize readily accessible aldehydes to create substituted isoxazolines...

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