Poster Archives - Page 3 of 10

Shortened Cardio-Metabolic Mouse Model of HFpEF

Current preclinical murine models of heart failure with preserved ejection fraction (HFpEF) require prolonged modeling periods, posing significant challenges for...

Efficacy of a TL1A Antibody in an Acute Colitis Mouse Model

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

GLP1R and GIPR Dual-Target Drugs in Humanized GIPR Mice

Multi-target drugs targeting GLP1R/GIPR/GCGR have demonstrated superior efficacy for weight loss and glycemic control compared to single-target GLP1R drugs. However,...

Evaluations of Targeted Delivery Systems for RNA Therapeutics

RNA therapeutics can target specific mRNAs with high specificity, making them advantageous for treating genetic diseases caused by known mutations....

Integrated Platform Supporting ASO Drug Discovery

Antisense oligonucleotides (ASOs) are single-stranded, synthetic chains of DNA or RNA designed to bind to specific RNA sequences through complementary...

Evaluating Off-Targets of siRNA Drugs

siRNA holds great promise as a therapeutic modality due to its high specificity, developability, and sustained efficacy. However, its application...

Efficacy of a Cell Therapy Drug on Kainic Acid-Induced Seizures

Epilepsy is one of the most common neurological disorders, and cell therapy is a promising area of research that has...

Efficacy of Xanomeline on Cognitive Dysfunction

Psychotropic drug abuse, particularly involving amphetamines and ketamine, has been shown to induce alterations in dopaminergic innervation, neuronal structure, and...