Knowledge Library

Structure determination: comparison of methods

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.

Resource Type: Brochure
Resource Topic: Structural Biology

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Early in vitro safety panel – Assays and Data Summary

In vitro Biology Services |  Early in vitro safety panel – Assays and Data Summary Functional Assays Radio ligand binding Assays

Resource Type: Brochure
Resource Topic: in vitro biology

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One-Stop Target-to-Hit Solutions

WuXi AppTec  | Target-to-Hit Solutions Protein Production  | All Target Classes and Challenging Proteins Biophysical & Biochemical Platforms |  Ready-To-Go Assay for Broad Range of Drug Targets Structural Biology Platforms Fragment Library & Screening ~3100 “Rule of three” compliant fragments

Resource Type: Brochure
Resource Topic: Hit Finding and Screening Services Structural Biology

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DELpro: A New Method of Hit Discovery

DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost. In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, …Read More >

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL)

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Target Discovery & Validation

Target Discovery and Validation Propelled by CRISPR and Other New Technologies Library screen platform CRISPR based AGMTM (advanced gene manipulation) platform Diversified cell bank Comprehensive functional and phenotypic assay

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CAR-T TCR-T

Integrated Platforms To Accelerate CAR-T/TCR-T Programs Comprehensive target validation program OXGENE based target expression system ensure high-efficiency delivery Systematic in vitro functional & safety assays in vivo efficacy studies Well-established genomic editing technology in primary immune cells

Resource Type: Brochure
Resource Topic: CAR-T Target Validation

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Targeted Protein Degradation Platform PROTAC

PROTAC BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation PROTAC CHEMISTRY PROTAC specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and …Read More >

Resource Type: Brochure
Resource Topic: PROTAC

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Antibody and Protein Preparation Services

Integrated Drug Discovery Platform for Antibody & Protein Preparation From Shanghai, Suzhou in China to Munich in Germany, more than 100 senior scientists are dedicated to offer an integrated and cost-effective service of polyclonal antibody and monoclonal antibody including: antigen design and preparation, anti-drug antibodies (ADA), host cell protein (HCP) antibodies, surrogate antibodies, diagnostic antibody, …Read More >

Resource Type: Brochure
Resource Topic: Protein Services

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One-stop DEL services from target to hit series – DELpro

WuXi AppTec  provides a one-stop solution for DEL services from target to hit series. Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL)

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