Knowledge Library

Nephropathy Research Platform

Kidney diseases are complex conditions caused by a variety of factors, including autoimmune diseases, metabolic disorders, infections, drug side effects, and genetics. Kidney diseases can lead to a range of complications, including kidney failure, anemia, electrolyte imbalances, and nerve damage, thereby affecting the quality of life. To drive breakthroughs in this critical field, WuXi AppTec …Read More >

Resource Type: Brochure
Resource Topic: Autoimmune and Inflammatory Diseases, in vivo Pharmacology, Metabolic Diseases

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Women’s Health Platform

Women’s health care is crucial not only for the well-being of individual women but also for the health and prosperity of families and communities. Despite significant medical advancements, there remains a concerning gap in the availability of effective drugs for common women-related diseases such as endometriosis, menopause syndromes, polycystic ovary syndrome (PCOS), and various forms …Read More >

Resource Type: Brochure
Resource Topic: in vivo Pharmacology, Metabolic Diseases, Oncology

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Metabolic Disease Services Platform

Metabolic diseases are considered to arise from multiple factors (such as genetics, diet, age, and environmental factors) and often affect various organs throughout the body.  No single cause is solely responsible for these disorders. To support research in this area, WuXi AppTec offers a comprehensive platform of in vitro and in vivo services.  Our capabilities …Read More >

Resource Type: Brochure
Resource Topic: Metabolic Diseases

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Pulmonary Disease Platform

WuXi AppTec offers a comprehensive platform of pulmonary disease-related services.  We provide a wide panel of validated disease models, including pulmonary fibrosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease. Our experts utilize advanced technologies with fully equipped invasive and non-invasive systems, such as the pulmonary function test system.

Resource Type: Brochure
Resource Topic: in vivo Pharmacology, Respiratory Diseases

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Fragment-based Drug Discovery

Fragment-based drug discovery is one of the most well-developed approaches for projects starting from small, low-affinity compounds.  Powerful biophysical and structural biology tools enable the study of large numbers of fragments and are opening new possibilities in the treatment of various diseases. WuXi AppTec offers a comprehensive fragment screening platform to support hit-to-lead optimization workflows. …Read More >

Resource Type: Brochure
Resource Topic: Fragment-Based Drug Discovery

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One Stop Target-to-Hit Platform: SOS1

The Son of Sevenless (SOS) protein is a guanine nucleotide exchange factor that acts as a key activator for KRAS function. The binding between KRAS and SOS helps facilitate the turnover of GDP-loaded KRAS (“off” state) into its GTP-loaded “on” state.  Disrupting the SOS1-KRAS complex with an SOS1 binder is a compelling strategy to help …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Structural Biology, X-ray Crystallography

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One Stop Target-to-Hit Platform: RAS Family

The RAS family of small GTPases are among the most frequently mutated oncogenes in human cancer. Previously viewed as undruggable, the recent FDA approval of two KRAS G12C-selective inhibitors has offered real promise to the development of anti-RAS therapies, including mutation-specific strategies. To support the discovery of novel KRAS inhibitors, WuXi AppTec offers a comprehensive …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Structural Biology, X-ray Crystallography

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One Stop Target-to-Hit Platform: CRBN-DDB1

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of this complex, and this protein is a key target for the action of small molecules.  Targeting of CRBN can modify its substrate specificity towards non-physiological proteins, which are subsequently ubiquitinated and degraded by the proteasome. …Read More >

Resource Type: Brochure
Resource Topic: Biophysical Assays, Structural Biology, X-ray Crystallography

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One Stop Target-to-Hit Platform: p53

TP53 is the most frequently mutated tumor suppressor gene in human cancer. Mutant p53 proteins not only lose wild-type p53-dependent tumor suppressive functions, but also frequently acquire oncogenic gain-of-functions that promote tumorigenesis.  Small molecules that can either protect p53 from negative regulators or restore the functionality of mutant p53 proteins are gaining interest, and potential drugs …Read More >

Resource Type: Brochure
Resource Topic: Biophysical Assays, Structural Biology, X-ray Crystallography

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Resource Topics
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