Knowledge Library

Pain Discovery Assays & in vivo Studies

WuXi Discovery Services supports all of your research needs, including target discovery, in vitro and in vivo pharmacology, translational research and clinical biomarker testing, to enable drug discovery for your target compound for pain. Full-scale molecular characterizations from gene/protein expression in vitro functional assays with validation of GPCR, Kinase and ion channel targets Selectivity profiling …Read More >

Resource Type: Brochure
Resource Topic: Pain

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond

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Resource Topic: Drug Discovery

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Structure determination: comparison of methods

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.

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Resource Topic: Structural Biology

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Early in vitro safety panel – Assays and Data Summary

In vitro Biology Services |  Early in vitro safety panel – Assays and Data Summary Functional Assays Radio ligand binding Assays

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Resource Topic: in vitro biology

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One-Stop Target-to-Hit Solutions

WuXi AppTec  | Target-to-Hit Solutions Protein Production  | All Target Classes and Challenging Proteins Biophysical & Biochemical Platforms |  Ready-To-Go Assay for Broad Range of Drug Targets Structural Biology Platforms Fragment Library & Screening ~3100 “Rule of three” compliant fragments

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Resource Topic: Hit Finding and Screening Services Structural Biology

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DELpro: A New Method of Hit Discovery

DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost. In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, …Read More >

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL)

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Target Discovery & Validation

Target Discovery and Validation Propelled by CRISPR and Other New Technologies Library screen platform CRISPR based AGMTM (advanced gene manipulation) platform Diversified cell bank Comprehensive functional and phenotypic assay

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CAR-T TCR-T

Integrated Platforms To Accelerate CAR-T/TCR-T Programs Comprehensive target validation program OXGENE based target expression system ensure high-efficiency delivery Systematic in vitro functional & safety assays in vivo efficacy studies Well-established genomic editing technology in primary immune cells

Resource Type: Brochure
Resource Topic: CAR-T Target Validation

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Targeted Protein Degradation Platform PROTAC

PROTAC BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation PROTAC CHEMISTRY PROTAC specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and …Read More >

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Resource Topic: PROTAC

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