WuXi Biology GPCR Cell Lines and Assays

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes and play a pivotal role in signaling pathways, making these transmembrane proteins an important drug target class.  In recent years, GPCR drug discovery has moved from random ligand screening towards structure-based drug design.

WuXi Biology has developed an integrated GPCR platform, featuring 150 GPCRs and over 100 GPCR cell lines. 

In the area of glucagon-like peptide-1 (GLP-1) receptor agonists, we provide end-to-end solutions to support drug discovery and development, from cell line construction and compound screening to in vitro mechanism studies, in vivo efficacy models, pharmacokinetics, and drug safety evaluations.

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