Resources Archive - Page 4 of 47

Targeting MC4R with Setmelanotide Improves Metabolic Parameters in DIO Mice

The global obesity epidemic is a significant public health concern, increasing the risk of various chronic diseases, including diabetes, cardiovascular...

Targeting the CB1 Receptor for Enhanced Obesity Management

Obesity is a significant risk factor for developing conditions like type 2 diabetes, heart disease, stroke, and several types of...

Native Mass Spectrometry Facilitates Validation of DEL Hits

Hit validation is a crucial step in drug discovery based on DNA-encoded libraries (DEL). Rapid and accurate resynthesis of compounds,...

Discovery of a Novel CD39 Inhibitor by DEL Screening

The ATP-adenosine pathway plays a crucial role in regulating immune responses, including those involved in combating tumors. CD39 is an...

Key Steps in Validating Targeted Protein Degraders

Choose excellence, choose WuXi Biology – your reliable partner in Targeted Protein Degradation (TPD) drug discovery. Since 2016, we have...

OncoWuXi Express: Animal Models of Parkinson’s Disease

Introduction： OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as...

ADC Development: Preclinical Pharmacology Essentials

Antibody-drug conjugates (ADCs) are increasingly demonstrating their value in cancer treatment, especially in combination therapies and for targeting resistant cancer...