Abstract Antibody drug conjugates (ADCs) are promising complexes with therapeutic potential that aimed to the treatment of solid tumor and hematological malignancies. Compared with the therapeutic monoclonal antibody, an ADC-derived monoclonal antibody is conjugated with cytotoxic agents (payloads) which can deliver potent cellular toxins to targeted cancer cells specifically. We have established a state-of-the-art platform …Read More >

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes and play a pivotal role in signaling pathways, making these transmembrane proteins an important drug target class.  In recent years, GPCR drug discovery has moved from random ligand screening towards structure-based drug design. WuXi Biology has developed an integrated GPCR …Read More >

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