MSU-Induced Acute Gouty Arthritis Mouse Model

Gouty arthritis is a common, painful inflammatory condition characterized by the deposition of monosodium urate (MSU) crystals in joints. This condition is often associated with metabolic complications such as hyperuricemia, obesity, insulin resistance, and dyslipidemia, which can exacerbate the severity and progression of the disease.

To better understand the pathophysiology and potential treatments for this condition, WuXi Biology developed an acute gouty arthritis model in mice, induced by intra-articular injection of MSU crystals. Through a case study, the authors presented a poster at the Obesity Week 2025 conference showcasing the effectiveness of this model and demonstrating the potential of an NLRP3 inflammasome inhibitor to blunt the early proinflammatory cascade initiated by MSU crystals.

Poster_Obesity Week 2025_MSU-Induced Acute Gouty Arthritis Mouse Model

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