Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify binders of target proteins. These topics will be discussed within the context of PROTAC lead optimization.

Key Learning Objectives:

• Leveraging DNA-encoded libraries (DEL) to identify binders to target proteins
• Accelerating the optimization of PROTACs towards preclinical candidate selection
• PROTAC Discovery and Chemistry Workflow