Imiquimod-induced Psoriasis-like Dermatitis in NHP

Psoriasis is a chronic autoimmune skin disease characterized by abnormal keratinocyte proliferation and infiltration of inflammatory cells.  The absence of a suitable animal model that accurately mimics the complex phenotype of psoriasis in humans has hindered the development of promising therapeutics to treat this condition.

At SITC 2024, WuXi AppTec presented a poster showcasing the use of imiquimod to induce psoriasis-like biological and pathological symptoms in NHPs, aiming to facilitate the efficacy evaluation of potential psoriasis treatments.  The authors demonstrate that this NHP model can replicate key pathological features of human psoriasis, including clinical appearance, histological changes, and inflammatory cytokine profiles.

Poster_SITC-2024_Imiquimod-induced Psoriasis-like Dermatitis in Rhesus Monkey

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