Design, Synthesis & Screening of Natural Product DEL

DNA-encoded library (DEL) technology has been recognized as a major screening method, offering unique advantages through its ability to provide vast chemical diversity and multiplexed affinity-based screening. Current DEL libraries mainly focus on small molecules and peptides, with only limited cases reported on natural products. Natural product molecules are well-known for their unique advantages, particularly their diverse skeletons and structural complexity.

At DEL Symposium 2025 in Boston, WuXi AppTec presented a poster demonstrating the feasibility of constructing natural product-based DEL libraries and their application for affinity screening (via a case study with the target acetylcholinesterase), to further expand the drug discovery chemical space.

Poster_2025 DEL Symposium_Natural Product DEL

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