Accelerating CIP Discovery with ASMS and DEL

Chemical inducers of proximity (CIPs) are small molecules that induce the proximity of two biological targets, usually proteins. Molecular glues and PROteolysis TArgeting Chimeras (PROTACs®) are among the best-known CIPs. These molecules utilize the endogenous E3-based proteolysis pathway to induce proximity between the target protein and E3 ligase, thereby triggering targeted protein degradation.

At the 2025 SLAS conference in San Diego, WuXi AppTec presented a poster describing how a small molecule diversity library can be used for CIP discovery by affinity selection mass spectrometry (ASMS). The authors further demonstrate how focused, bivalent DNA-encoded libraries (DELs) and diversity DELs can be used for the direct discovery of PROTACs and molecular glues, respectively.

SLAS 2025 Poster_Accelerating CIP Discovery with ASMS and DEL

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