One Stop Target-to-Hit Platform: SOS1
The Son of Sevenless (SOS) protein is a guanine nucleotide exchange factor that acts as a key activator for KRAS function. The binding between KRAS and SOS helps facilitate the turnover of GDP-loaded KRAS (“off” state) into its GTP-loaded “on” state. Disrupting the SOS1-KRAS complex with an SOS1 binder is a compelling strategy to help treat KRAS-driven cancers.
To support SOS1-targeted drug discovery, WuXi AppTec offers a comprehensive panel of ready-to-go biophysical assays, nucleotide exchange assays, and established X-ray crystallography protocols. Our high-quality protein production platform includes the KRAS-SOS1 protein complex.
Target of the month_SOS1
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