Knowledge Library

Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries

Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding in vitro biology Phenotypic Assays Screening Libraries Small Molecules Target Identification and Validation

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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HIJACKING CELLULAR MECHANISMS TO TREAT COMPLEX DISEASES

Resource Type: White Paper
Resource Topic: Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays DRUG DISCOVERY AND INNOVATION in vitro biology Oligonucleotides Oncology Rare Diseases Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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RARE DISEASES: OPPORTUNITIES AND CHALLENGES FOR TREATMENTS DELIVERED BY ADENO-ASSOCIATED VIRUSES

Resource Type: White Paper
Resource Topic: Biomarkers Gene Therapies in vivo Pharmacology Rare Diseases Target Identification and Validation

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Optimizing Drug Pipelines With Biophysical Methods

Download our whitepaper on how using biophysical techniques can enhance and streamline processes throughout the drug discovery and validation cycle. Discover fresh opportunities to characterize challenging drug targets, examine biophysical screening methods, and look toward what’s next for biophysical methods in drug discovery.

Resource Type: White Paper
Resource Topic: Biochemical Assays Biophysical Assays Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays

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Developing drug-induced resistant tumor models for efficacy evaluation of next-generation anticancer therapies

The therapeutic landscape of cancer has been transformed over the last few decades. Our understanding of cancer and its therapeutic approach has improved greatly due to advanced cancer biology, functional imaging and next–generation sequencing. One of the key challenges in cancer therapy is how to effectively kill cancer cells while leaving normal cells intact. As …Read More >

Resource Type: Poster
Resource Topic: Biomarkers in vivo Pharmacology Oncology Target Identification and Validation Tumor Models

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Developing a panel of orthotopic syngeneic tumor models for IO drug discovery

The efficacy of immuno-oncology therapies needs to be evaluated in animal models with functional immune systems. Syngeneic tumor models are established by inoculating mouse cancer cell lines into immunocompetent mice with the same genetic background. The host mice have complete immune activity and show histocompatibility with homograft tumor tissues, which can maximize the simulation of …Read More >

Resource Type: Poster
Resource Topic: Antibodies in vivo Pharmacology Lead Optimization Oncology Target Identification and Validation Tumor Models

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Development of an integrated in vitro and in vivo OVA-specific system for cancer vaccine discovery

We have established an advanced and integrated in vitro and in vivo platform for various types of cancer vaccines, including peptide vaccines, mRNA vaccines, DC vaccines and more. Ovalbumin (OVA) is a key model antigen which has been widely used in vaccination experiments. Here we established an OVA overexpressed system based on different types of …Read More >

Resource Type: Latest Science Poster
Resource Topic: Biomarkers Cell-based Assays Immunology in vitro biology Lead Optimization Oncology Target Identification and Validation Target-Specific Assays Tumor Models

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Structure determination: comparison of methods

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.

Resource Type: Brochure Infographic
Resource Topic: Biophysical Assays Cells and Protein Science Hit Finding Hit-to-Lead Lead Optimization Structural Biology Target Identification and Validation

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Resource Topics
× peptide, amino acid

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