Knowledge Library

DNA-encoded chemical libraries

https://www.nature.com/articles/s43586-021-00084-5  Abstract DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to discover small molecules capable of modulating biologically relevant targets. DECL synthesis starts with an oligonucleotide that contains a chemical linker moiety, and proceeds through iterative cycles of DNA barcode elongation and chemical synthesis. DECL selections require little protein, minimal assay development …Read More >
Resource Type: Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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Introduction into Fragment Based Drug Discovery

Fragment-based drug discovery (FBDD) is a method used for finding hit compounds as one strategy of hit identification in the drug discovery process. Fragments are small molecules with a low molecular weight, smaller than lead molecules or druglike molecules. The FBDD technology is based on identifying small chemical fragments, which bind to the biological target …Read More >
Resource Type: Latest Science Webinar
Resource Topic: Discovery Chemistry Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding in vitro biology Phenotypic Assays Screening Libraries Small Molecules Target Identification and Validation

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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Optimizing Drug Pipelines With Biophysical Methods

Download our whitepaper on how using biophysical techniques can enhance and streamline processes throughout the drug discovery and validation cycle. Discover fresh opportunities to characterize challenging drug targets, examine biophysical screening methods, and look toward what’s next for biophysical methods in drug discovery.
Resource Type: White Paper
Resource Topic: Biochemical Assays Biophysical Assays Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Resource Type: Publication
Resource Topic: Antibodies CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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DNA-encoded chemical libraries
Resource Type: Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

VIEW

Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Resource Type: Publication
Resource Topic: Antibodies Biomarkers Cells and Protein Science CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

VIEW

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