Knowledge Library

DNA-encoded chemical libraries

https://www.nature.com/articles/s43586-021-00084-5  Abstract DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to discover small molecules capable of modulating biologically relevant targets. DECL synthesis starts with an oligonucleotide that contains a chemical linker moiety, and proceeds through iterative cycles of DNA barcode elongation and chemical synthesis. DECL selections require little protein, minimal assay development …Read More >

Resource Type: Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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Introduction into Fragment Based Drug Discovery

Fragment-based drug discovery (FBDD) is a method used for finding hit compounds as one strategy of hit identification in the drug discovery process. Fragments are small molecules with a low molecular weight, smaller than lead molecules or druglike molecules. The FBDD technology is based on identifying small chemical fragments, which bind to the biological target …Read More >

Resource Type: Latest Science Webinar
Resource Topic: Discovery Chemistry Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation

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Discovery Newsletter November 2022

Resource Type: Latest Science Newsletter
Resource Topic: CAR-T Cell Cell-based Assays Chemical Biology and Proteomics Discovery Chemistry DRUG DISCOVERY AND INNOVATION in vitro biology Oligonucleotides Oncolytic Viruses Safety and Early Toxicity Small Molecules Target Identification and Validation Target-Specific Assays

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How Does It Work? | Adenovirus Vaccines

This week, we delve into Adenovirus Vaccines as part of our “How Does It Work?” 3D MoA animation series examining biotech topics on a molecular level. In 2020, the World Health Organization declared the Covid-19 outbreak a pandemic, but not all viruses are bad news. Adenoviruses are a family of viruses that can be used …Read More >

Resource Type: Video
Resource Topic: DRUG DISCOVERY AND INNOVATION Gene Therapies Infectious Diseases Target Identification and Validation

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WuXi AppTec Oligonucleotide Biology Platform

WuXi Biology oligonucleotide capabilities Sequence design Knockdown effect incell lines and primary cells (transfection d f uptake) Splicing analysis Functional assays Other assays: Tm determination Cytotoxicity lmmunotoxicity Off-target effect “Humanized” mouse models Transgenic, HDI and AAV mouse models NHP models Short and longterm KD efficacy/ harmacology readouts GalNAc-ASGPR delivery system SPR screening Customized assays for …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays Candidate Selection Cell-based Assays Discovery Chemistry Gene Manipulation Gene Therapies Hit-to-Lead in vivo Pharmacology Lead Optimization Liver Diseases Oligonucleotides Rare Diseases Safety and Early Toxicity Target-Specific Assays

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How Does It Work? | RNAi

As part of our dedication to providing an #openaccess platform, so our entire ecosystem can come together to share #science & #collaborate to better the lives of all #patientsfirst. We’ve created MoA animations in our new series exploring biotech topics on a molecular level. Protein malfunctions cause many diseases, but a new approach is emerging …Read More >

Resource Type: Video
Resource Topic: Autoimmune and Inflammatory Diseases Cardiovascular & Metabolic Diseases Central Nervous System & Pain DRUG DISCOVERY AND INNOVATION Gene Manipulation Gene Therapies Liver Diseases Metabolic Diseases Oligonucleotides Oncology Ophthalmology Rare Diseases Target Identification and Validation

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Oligonucleotide Drug Discovery

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. In this webinar, …Read More >

Resource Type: Webinar
Resource Topic: Biochemical Assays Cell-based Assays Discovery Chemistry Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Oligonucleotides Safety and Early Toxicity

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond

Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Integrating Practical Machine Learning and Quantum Mechanics Tools to Synthesis in Medicinal Chemistry

Resource Type: Presentation Video
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry in silico services Quantum Mechanics Small Molecules

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