Central Nervous System & Pain Archives - Page 2 of 4

OncoWuXi Express: Animal Models of Parkinson’s Disease

Introduction： OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as...

Epilepsy Animal Models

Epilepsy is a chronic brain disorder characterized by recurring seizures, which are episodes of uncontrolled and abnormal electrical activity in...

Rare Neurological Disease Animal Models

Rare neurological diseases are conditions affecting the nervous system that occur infrequently, with examples including Huntington’s disease, Rett syndrome, and...

Neurobiology Services Platform

As part of our neurobiology services platform, WuXi AppTec offers a comprehensive panel of advanced technologies and validated disease models to...

Heme Oxygenase-1-Targeting Molecules

WuXi AppTec scientists published a study in the open access archive ChemRxiv describing the discovery of highly selective, novel, heme...

TAAR1 as an Emerging Target for the Treatment of Psychiatric Disorders

A growing body of in vitro and in vivo evidence has demonstrated that trace amine-associated receptor 1 (TAAR1) could negatively...

Dianthus Platform: Screening for CRBN-DDB1 Proteolysis-Targeting Chimeras and Molecular Glues

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of...

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders. WuXi...

Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies

Animal studies may provide a close approximation to humans when addressing the key challenge of clinical translatability. In the preclinical...

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