Knowledge Library

PD-1 Blockade Protein in 4th Generation Armored CAR-T Cells Enhances Cytotoxicity Effect with in vitro Re-challenge System

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that express a surface receptor to recognize tumor-associated antigens (TAA). CAR-T cell therapy have demonstrated remarkable success with hematological malignancies. However, limited headway has been made towards solid tumor, due to various challenges, including recognition of tumor-specific antigen trafficking and penetration, localization and survival within …Read More >
Resource Type: Latest Science, Poster
Resource Topic: Antibodies, Biomarkers, CAR-T Cell, Cell Therapies, Cell-based Assays, Cells and Protein Science, Oncology, Target Identification and Validation

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OncoWuXi Newsletter: June 2022

WuXi AppTec xenograft and syngeneic tumor models in rats and CD47-related in vitro assay platform
Resource Type: Newsletter
Resource Topic: Antibodies, Cell-based Assays, Hit-to-Lead, in vivo Pharmacology, Lead Optimization, Oncology, Target-Specific Assays, Tumor Models

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Developing a panel of orthotopic syngeneic tumor models for IO drug discovery

The efficacy of immuno-oncology therapies needs to be evaluated in animal models with functional immune systems. Syngeneic tumor models are established by inoculating mouse cancer cell lines into immunocompetent mice with the same genetic background. The host mice have complete immune activity and show histocompatibility with homograft tumor tissues, which can maximize the simulation of …Read More >
Resource Type: Poster
Resource Topic: Antibodies, in vivo Pharmacology, Lead Optimization, Oncology, Target Identification and Validation, Tumor Models

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Cancer Immunotherapy and the Application of In Vitro Immunoassays in Drug Development
Resource Type: Webinar
Resource Topic: Antibodies, Autoimmune and Inflammatory Diseases, Biochemical Assays, Cell-based Assays, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Phenotypic Assays, Small Molecules, Target Identification and Validation, Target-Specific Assays

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Optimizing Drug Discovery Pipelines with Biophysical Methods
Resource Type: Webinar
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Biophysical Assays, Cell-based Assays, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Mass Spectrometry-based Assays, Oncology, Phenotypic Assays, Screening Libraries, Small Molecules, Structural Biology, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation

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Antibody and Protein Preparation Services

Integrated Drug Discovery Platform for Antibody & Protein Preparation We are dedicated to offering an integrated and cost-effective services platform of polyclonal and monoclonal antibodies, including: Antigen design and preparation Anti-drug antibodies (ADA) Host cell protein (HCP) antibodies Surrogate antibodies Diagnostic antibodies Therapeutic antibodies Learn about our services platform for evaluating bispecific antibodies
Resource Type: Brochure
Resource Topic: Antibodies, Cells and Protein Science, Immunology, Target Identification and Validation

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Immuno-Oncology Services

Immuno-oncology Platform An outstanding platform to enable cancer immunotherapy with one stop service: Immunological function assessment TIL analysis – Flowcytometry, Multiplex IF and Cytex Animal models – Syngeneic and humanized models Immune profiling by NGS – Single Cell RNAseq, Mutation burden and TCR/BCR repertoire Clinical biomarker services – CAP certification and GCP compliance
Resource Type: Brochure
Resource Topic: Antibodies, Autoimmune and Inflammatory Diseases, Biomarkers, Cell-based Assays, Cells and Protein Science, Hit-to-Lead, Immunology, in vivo Pharmacology, Lead Optimization, Oncology, Phenotypic Assays, Target Identification and Validation, Target-Specific Assays, Tumor Models

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >
Resource Type: Brochure
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Chemical Biology and Proteomics, Gene Therapies, High-throughput screening (HTS), Hit-to-Lead, Immunology, in vitro biology, in vivo Pharmacology, Lead Optimization, Oncology, Screening Libraries, Small Molecules, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation, Tumor Models

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