Knowledge Library

Combating Drug Resistance in Cancer Therapy

An inevitable challenge emerges over time as tumors develop drug resistance, resulting in treatment failure. This resistance is inherent to the tumor cells themselves, as well as tied to factors within the tumor microenvironment (TME). To bolster the research of innovative cancer drugs and to emulate real-world clinical scenarios of tumor resistance, WuXi Biology has …Read More >

Resource Type: Video
Resource Topic: Oncology, Tumor Models

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Poster Presentations at IMMUNOLOGY2024

Join WuXi AppTec at IMMUNOLOGY2024™. For this year’s annual meeting of the American Association of Immunologists (AAI), WuXi Biology has been selected to present five noteworthy posters, showcasing our panel of preclinical models representing urticaria, nephritis, rheumatoid arthritis, gout, and atopic dermatitis. Stop by Booth 777 to get your questions answered by one of our …Read More >

Resource Type: Video
Resource Topic: Immunology, in vivo Pharmacology

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PROTAC Optimization Strategies

What if a constructed PROTAC with a confirmed high-affinity warhead doesn’t work as expected? That means we need to take a closer, more careful look at how it’s designed and how it works. In this video, our expert from WuXi Biology shares strategies to address such an R&D scenario.

Resource Type: Video
Resource Topic: Lead Optimization, Targeted Protein Degradation

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Novel Approaches to Targeted Protein Degradation

In the last decade, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms. As of now, over 20 targeted protein degraders have advanced into clinical development. WuXi AppTec has built a robust TPD discovery chemistry platform. We deliver synthetic and medicinal chemistry …Read More >

Resource Type: Video
Resource Topic: Discovery Chemistry, Targeted Protein Degradation

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Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >

Resource Type: Presentation, Video
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Mass Spectrometry-based Assays, Oligonucleotides, Small Molecules

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Biophysical and Structural Biology Methods Enable Fragment-based Covalent Ligand Discovery of Human BTK

Drug Discovery Chemistry Conference 2023 Powerful biophysical and structural biology tools enable the study of large numbers of covalent fragments and are opening up new possibilities in the treatment of various diseases. Here, Dr. Moran Jerabek-Willemsen, Head of Biophysics & Screening in WuXi Biology reports the results of a covalent FBDD project on Bruton’s Tyrosine …Read More >

Resource Type: Presentation, Video
Resource Topic: Biochemical Assays, Biophysical Assays, Discovery Chemistry, Fragment-Based Drug Discovery, Hit-to-Lead, Lead Optimization, Mass Spectrometry-based Assays, Screening Libraries, Small Molecules, Structural Biology

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DNA-Encoded Libraries for the Discovery of Small-Molecule Hits

Drug Discovery Chemistry Conference 2023 DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel chemical matter that modulates protein targets of interest.  Point-by-point, Dr. Alex Satz, Executive Director, WuXi Biology will discuss the primary challenges and limitations of DEL screening, and concisely state the current abilities of the technology …Read More >

Resource Type: Presentation, Video
Resource Topic: DNA-Encoded Library (DEL), Hit Finding, in silico services, Screening Services, Small Molecules

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How Does It Work? | Protein Based Vaccines

When a new pathogen invades, it’s a race against time for your immune system to stop it from multiplying out of control. This week, we explore Protein Based Vaccines as part of our “How Does It Work?” series. Fortunately, #vaccines give your immune system a head start against dangerous pathogens. A protein-based vaccine, like this …Read More >

Resource Type: Video
Resource Topic: Cells and Protein Science, Infectious Diseases, Target Identification and Validation

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How Does It Work? | Adenovirus Vaccines

This week, we delve into Adenovirus Vaccines as part of our “How Does It Work?” 3D MoA animation series examining biotech topics on a molecular level. In 2020, the World Health Organization declared the Covid-19 outbreak a pandemic, but not all viruses are bad news. Adenoviruses are a family of viruses that can be used …Read More >

Resource Type: Video
Resource Topic: DRUG DISCOVERY AND INNOVATION, Gene Therapies, Infectious Diseases, Target Identification and Validation

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Resource Topics
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