Knowledge Library

DNA-encoded chemical libraries

https://www.nature.com/articles/s43586-021-00084-5  Abstract DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to discover small molecules capable of modulating biologically relevant targets. DECL synthesis starts with an oligonucleotide that contains a chemical linker moiety, and proceeds through iterative cycles of DNA barcode elongation and chemical synthesis. DECL selections require little protein, minimal assay development …Read More >

Resource Type: Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the …Read More >

Resource Type: Publication
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Oncology Small Molecules

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Resource Type: Publication
Resource Topic: Antibodies CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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DNA-encoded chemical libraries

Resource Type: Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

VIEW

Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Resource Type: Publication
Resource Topic: Antibodies Biomarkers Cells and Protein Science CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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