T-Cell Engagers: Integrated Workflow to Advance TCE Candidates
T-cell engagers (TCEs) are designed to redirect T cells toward tumor cells, offering a highly focused approach to immune-mediated killing. Their development, however, requires careful evaluation across multiple stages to balance activity, specificity, and translational relevance.
WuXi AppTec’s integrated TCE workflow supports candidate progression through:
✅ TCE generation, production, characterization, and screening
✅ In vitro cytotoxicity, T-cell activation, and cytokine release
✅ In vivo pharmacology with knock-in, hPBMC, and hHSC models
✅ PK, dose-response, and initial in vivo safety assessment
Watch the video to learn more.
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