Stress Model for Antidepressant Drug Discovery

Stress is a major environmental risk factor that triggers depressive episodes, inducing symptoms such as anhedonia, negative cognitive bias, and social withdrawal through mechanisms including hyperactivity of the HPA axis, neuroinflammation, and impaired neuroplasticity.

Rodent stress models, including CUMS (Chronic Unpredictable Mild Stress), CSDS (Chronic Social Defeat Stress), and LH (Learned Helplessness), reproduce key features of human depression across behavioral, molecular, and physiological levels, and exhibit repeatable, quantifiable responses to antidepressant treatments. WuXi Biology offers rodent CUMS models validated with multiple psychiatric medications to accelerate the development of next-generation antidepressant treatments.

Stress Model for Antidepressant Drug Discovery

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