Tissue transglutaminase (TG2) is a multifunctional enzyme activated in several pathological conditions, including cancer. WuXi AppTec recently contributed to a...
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Animal studies may provide a close approximation to humans when addressing the key challenge of clinical translatability. In the preclinical...
Continue Reading Within the PI3K family, the heterodimer protein comprising the p110-α and p85-α catalytic/regulatory subunits (encoded by PIK3CA and PIK3R1) are...
Continue Reading Protein arginine methyltransferase 5 (PRMT5) is an enzyme which plays an essential role in a wide range of cellular processes. ...
Continue Reading Cyclin-dependent kinase 2 (CDK2) and its respective cyclin E1 and cyclin A2 complexes are essential to driving abnormal growth processes...
Continue Reading Werner syndrome helicase (WRN) is a key drug target for cancers with microsatellite instability. To support the discovery of potent...
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In this webinar, we present the latest advances and challenges facing researchers focused on new and emerging modalities in drug...
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Designing effective oligonucleotide therapeutics for clinical applications involves understanding both the chemistry and biology of nucleic acids. In this white...
Continue Reading DELvision is a powerful DNA encoded library (DEL)-based toolset for AIphaFold-assisted drug discovery and target sciences. In contrast to conventional...
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