Paclitaxel-Induced Resistant Tumor Models

Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The mechanisms for resistance to paclitaxel include drug efflux transporter overexpression, altered apoptotic gene expression, and changes associated with microtubules to reduce the influence of this chemotherapeutic agent.

WuXi Biology has established gastric cancer and breast cancer cell lines that are stably resistant to paclitaxel.  We have also established corresponding in vivo tumor models for these cell lines which exhibit significant resistance.