Creating a Biological Switch Using DEL Technology

In addition to identifying chemical starting points for early drug discovery processes, DNA-encoded library (DEL) technology has now expanded to new applications, including the discovery of bifunctional affinity ligands historically considered difficult to develop.

At the 2024 Gordon Research Conference, WuXi AppTec presented a poster describing how DEL can enable the rapid discovery of novel affinity ligands, such as tracers for biochemical and cellular assays, and building a ‘universal’ chimeric antigen receptor (CAR) to enhance the control and safety profile of CAR-based immunotherapies.

Gordon Research Conference 2024_Biorganic Chemistry_Poster

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