Animal Disease Models of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a prevalent, chronic, autoimmune disease. The onset and progression of RA are closely associated with an aberrant immune response, in which immune cells accumulate excessively in target joints.  Most current, anti-rheumatic drugs only alleviate disease progression or ameliorate inflammation. Development of new RA therapies with increased efficacy represents an unmet medical need.

WuXi Biology utilized a collagen-induced arthritis mouse model to investigate the role of JAK inhibitors in RA pathogenesis.  This study provided valuable insights into immune modulation and the potential benefits of selective JAK inhibitors in RA treatment.