
Emergence of Irreversible Modulation in Drug Discovery
Irreversible covalent modulation is a crucial part of the drug discovery toolbox and is an important strategy for finding tractable equity against less druggable targets. However, understanding the binding kinetics, mechanistic PK/PD relationship and SAR of compounds is critical to success as is employing best practice in hit identification and lead optimization.
Join us in Cambridge on 16-17 October 2024, where we will bring together established leaders and emerging investigators exploring the use of irreversible covalent modulators in drug discovery.