Discovery on Target 2022
Discovery on Target (DOT) highlights advances in current and emerging “hot” targets and technologies, as well as target validation strategies for the discovery and development of novel therapeutic agents ranging from biologics to small molecules. The 20th Annual event brings back popular topics like PROTACs and RNA plus new programming on immunomodulation, antivirals, neurodegeneration targets, and KRAS.
Find our involvement through the scientific program and below, and don't forget to visit us in-person at booth 316.
|TARGETING mRNA | TUESDAY, OCTOBER 18 - 11:55 am EDT|
Discovery of RNA targeting small molecule using DNA-encoded library technology
Zhifeng Yu, PhD, Director, WuXi AppTec
By utilizing newly-developed DNA-encoded small molecule library technology (DEL), researchers are able to over come scalability challenges often seen in RNA-target drug discovery. This presentation will review the “DNA-Zipper” strategy proposed by WuXi AppTec. It has been shown to significantly reduce the interference between DNA tags from DEL molecules and RNA targets, and effectively decreases the false positive readouts.
DEGRADATION STRATEGIES FOR ONCOLOGY | TUESDAY, OCTOBER 18 - 2:30 pm EDT
Building a comprehensive platform for discovery and optimization of bifunctional molecules
Dave Madge, PhD, Vice President, WuXi AppTec
Therapeutic strategies that are based on using a multi-functional molecule to induce the proximity of two proteins, or indeed an oligonucleotide and a protein, have become increasingly well validated. In this presentation we will discuss some of the chemical and biological tools that have been developed to enable the discovery, characterization and optimization of such bifunctional, proximity-inducing, molecules and show how these tools can dramatically accelerate drug discovery in this area.
|Dr. Declan Ryan, Vice President Business Development at WuXi AppTec|
Dr. Dave Madge, Vice President of Discovery Services, WuXi AppTec
Dr. Alice Zhang, Director Strategy Support, WuXi AppTec
Dr. Zhifeng Yu, Director, WuXi AppTec
Dr. Moran Jerabek-Willemsen, Head of Biophysics & Screenings, WuXi AppTec
Dr. Quinn Z. Associate Director, Business Development, WuXi AppTec
John Shirley, Sr. Director of Sales & Marketing , WuXi AppTec