PBMC Humanized Tumor Models for Evaluating T-cell Engagers

T-cell engagers (TCEs) are a class of bispecific antibody-based immunotherapies designed to bring T cells into close proximity with cancer cells, triggering the immune system to kill the cancer cells. TCEs bind to the CD3 complex on T cells and a tumor-specific antigen on cancer cells.  The contact formed by the TCE creates an immunological synapse that mimics the natural immune interaction between a T-cell and a target cell.

PBMC-humanized tumor models are an effective tool for evaluating TCEs, as these models provide human T-cells (for engagement via CD3), human tumor antigens, and a functional immune-tumor interface that reflects aspects of the TCE mechanism.  WuXi AppTec offers a broad panel of in-house PBMC humanized tumor models for studying multiple cancer types against validated targets.

PBMC Humanized Tumor Models for Evaluating T Cell Engagers

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