Knowledge Library

Fragment Screening and Biophysical Hit Validation at WuXi AppTec’s HitS

Resource Type: Presentation, Video
Resource Topic: Biochemical Assays, Biophysical Assays, Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Lead Optimization, Small Molecules, Structural Biology

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Immuno-Oncology Platform to Enable Discovery from Target to Drug

Resource Type: Presentation, Video
Resource Topic: Biomarkers, Cell-based Assays, Cells and Protein Science, DRUG DISCOVERY AND INNOVATION, Hit Finding, Hit-to-Lead, Lead Optimization, Oncology, Screening Libraries, Target Identification and Validation, Tumor Models

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NASH Animal Models and their Clinical Relevance – Quantitative Histopathology of Hepatic Fibrosis

Resource Type: Webinar
Resource Topic: Biomarkers, Lead Optimization, Liver Diseases, Metabolic Diseases, NASH

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Cancer Immunotherapy and the Application of In Vitro Immunoassays in Drug Development

Resource Type: Webinar
Resource Topic: Antibodies, Autoimmune and Inflammatory Diseases, Biochemical Assays, Cell-based Assays, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Phenotypic Assays, Small Molecules, Target Identification and Validation, Target-Specific Assays

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Novel Peptide Hit Identification and Lead Generating Strategies for Drug Discovery

Resource Type: Webinar
Resource Topic: Cells and Protein Science, Hit-to-Lead, in vitro biology, Lead Optimization, Small Molecules, Target Identification and Validation

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Enabling Drug Discovery with Diverse Lead Generation Platforms

Resource Type: Webinar
Resource Topic: Discovery Chemistry, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, High-throughput screening (HTS), Hit Finding, Hit-to-Lead, in silico services, Lead Optimization, Mass Spectrometry-based Assays, Screening Libraries, Screening Services, Small Molecules, Structural Biology, Target Identification and Validation

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Aug 2021: Wuxi AppTec immune profiling in drug discovery and CLDN18.2-related tumor models.

Resource Type: Newsletter
Resource Topic: Candidate Selection, Cell-based Assays, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Tumor Models

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Empowering Organic Syntheses with Quantum Mechanics Analyses

Syntheses of specifically functionalized molecules continue to be rate limiting steps (RLS) in drug discovery. Improvement in this RLS means investing only in reactions/synthetic sequences that are more likely to succeed. Structural diversifications, different substitution patterns or unique heterocyclic systems can often adversely impact the crucial step(s) of established synthetic sequences or development of feasible …Read More >

Resource Type: Article
Resource Topic: Chemical Biology and Proteomics, Discovery Chemistry, Hit-to-Lead, in silico services, Lead Optimization, Quantum Mechanics, Small Molecules

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The Synthesis of an Entrepreneur: Merging a Passion for Biochemistry, Synthetic Chemistry, and Bioactive Molecules in Academia

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) Synthetic chemist Joseph Ready believes a huge amount of innovation in the drug industry comes from academia. Academic science is arguably the greatest source of innovation in our ecosystem, yet faces challenges when considering the transition from the lab to early stage …Read More >

Resource Type: Article
Resource Topic: Central Nervous System & Pain, Chemical Biology and Proteomics, Discovery Chemistry, High-throughput screening (HTS), Hit-to-Lead, Infectious Diseases, Lead Optimization, Oncology, Small Molecules, Target Identification and Validation

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Resource Topics
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