INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) Synthetic chemist Joseph Ready believes a huge amount of innovation in the drug industry comes from academia. Academic science is arguably the greatest source of innovation in our ecosystem, yet faces challenges when considering the transition from the lab to early stage …Read More >

In the past, thousands of proteins were considered undruggable. The restricted number of chemical entities available and classical methods limited the exploration of this undevelopable area. Today, the combination of novel chemical modalities and advanced technical approaches has resulted in new clinical candidates from previously undruggable targets. To accelerate your drug discovery campaign, WuXi AppTec´s …Read More >

Target Discovery and Validation Propelled by CRISPR and Other New Technologies Library screen platform CRISPR based AGMTM (advanced gene manipulation) platform Diversified cell bank Comprehensive functional and phenotypic assay

BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation CHEMISTRY Specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and analytical support on …Read More >

Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management:  we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >

Biomarker discovery Mouse clinical trial 61 PDX-derived primary cancer cell lines Drug-resistant xenograft models Combination therapy platform including radiation World leading genome sequencing and bioinformatics capability

One of the largest collection of Patient-Derived Xenograft (PDX) Tumor Models in Asia with genomic profiling 1200 PDX models Collection of PDX models prevalent in Asia 800+ PDX models with genetic profiling Searchable online database with mobile APP Integrated online database for PDX, CDX & Syngeneic tumor models with mobile App PDX with oncogene amplification, …Read More >

Immuno-oncology Platform An outstanding platform to enable cancer immunotherapy with one stop service: Immunological function assessment TIL analysis – Flowcytometry, Multiplex IF and Cytex Animal models – Syngeneic and humanized models Immune profiling by NGS – Single Cell RNAseq, Mutation burden and TCR/BCR repertoire Clinical biomarker services – CAP certification and GCP compliance