Knowledge Library

OncoWuXi Newsletter December 2022
Resource Type: Latest Science Newsletter
Resource Topic: Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Candidate Selection Cell-based Assays CRISPR/Cas9 DRUG DISCOVERY AND INNOVATION Hit Finding Hit-to-Lead Immunology Lead Optimization Oncology Phenotypic Assays Rare Diseases Target Identification and Validation Tumor Models

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How Does It Work? | CRISPR Mechanism

The CRISPR Cas9 System was first discovered as part of the bacterial adaptive immune response against viruses, but in recent years it’s revolutionized our techniques for genome editing. The Cas9 complex is formed of two components. A protein called Cas9 that can cut double stranded DNA, and a guide RNA, that binds to a specific …Read More >
Resource Type: Video
Resource Topic: CRISPR/Cas9 Gene Manipulation Gene Therapies in vivo Pharmacology Oncology Target Identification and Validation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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RARE DISEASES: OPPORTUNITIES AND CHALLENGES FOR TREATMENTS DELIVERED BY ADENO-ASSOCIATED VIRUSES
Resource Type: White Paper
Resource Topic: Biomarkers CRISPR/Cas9 Gene Manipulation Gene Therapies in vivo Pharmacology Rare Diseases Target Identification and Validation

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Cancer cells acquire genetic heterogeneity to escape from immune surveillance during tumor evolution, but a systematic approach to distinguish driver from passenger mutations is lacking. Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens …Read More >
Resource Type: Latest Science Publication
Resource Topic: Antibodies CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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WuXi Discovery Services Newsletter: February 2021
Resource Type: Newsletter
Resource Topic: CRISPR/Cas9 DNA-Encoded Library (DEL) Gene Manipulation Gene Therapies Target Identification and Validation Targeted Protein Degradation

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CRISPR Library Screen to Identify Driver Mutations of Tumor Growth and Metastasis
Resource Type: Webinar
Resource Topic: CRISPR/Cas9 Gene Manipulation Gene Therapies Oncology Rare Diseases Screening Libraries Target Identification and Validation

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Immuno-Oncology Platform to Enable Discovery from Target to Drug
Resource Type: Presentation Video
Resource Topic: Biomarkers Cell-based Assays Cells and Protein Science CRISPR/Cas9 DRUG DISCOVERY AND INNOVATION Hit Finding Hit-to-Lead Lead Optimization Oncology Screening Libraries Target Identification and Validation Tumor Models

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CRISPR library screens identify frequent cancer mutations regulating PD-1 blockade response

AACR Annual meeting 2021 Wenrong Zhou1,* , Min Long2,3* , Tianyu Song3,* , Qiangqiang Fan1 , Zhengang Peng1 , Yong Cang3 , Qunsheng Ji1  1 Oncology and Immunology Unit, Research Service Division, WuXi AppTec (Shanghai) Co., Ltd., China; 2 Life Sciences Institute, Zhejiang University, Hangzhou, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, …Read More >
Resource Type: Poster
Resource Topic: CRISPR/Cas9 Gene Manipulation Gene Therapies Oncology Phenotypic Assays Screening Libraries Target Identification and Validation

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