Knowledge Library

DEL Screening – DELight Handbook

DEL Screening | WuXi AppTec DELight Kit  Faster and Lighter Drug Discovery DELight kit containing 58 libraries and 10.8 billion compounds, buffers and a step-by-step online experimental manual. Drug developers perform affinity selection according to the manual and return the sample to WuXi AppTec upon completion.

Resource Type: Brochure
Resource Topic: Chemical Biology and Proteomics, DNA-Encoded Library (DEL), Hit Finding, Screening Libraries, Small Molecules, Target Identification and Validation, Targeted Protein Degradation

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Translational Oncology

Biomarker discovery Mouse clinical trial 61 PDX-derived primary cancer cell lines Drug-resistant xenograft models Combination therapy platform including radiation World leading genome sequencing and bioinformatics capability

Resource Type: Brochure
Resource Topic: Biomarkers, Candidate Selection, Cell-based Assays, Cells and Protein Science, Chemical Biology and Proteomics, Lead Optimization, Oncology, Phenotypic Assays, Tumor Models

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Patient-Derived Xenograft (PDX) Tumor Models

One of the largest collection of Patient-Derived Xenograft (PDX) Tumor Models in Asia with gene expression/mutation profiling 1200 PDX models Collection of PDX models prevalent in Asia 800+ PDX models with genetic profiling Searchable online database with mobile APP Integrated online database for PDX, CDX & Syngeneic tumor models with mobile App PDX with oncogene …Read More >

Resource Type: Brochure
Resource Topic: Biomarkers, in vivo Pharmacology, Lead Optimization, Tumor Models

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Immuno-Oncology Services

Immuno-oncology Platform An outstanding platform to enable cancer immunotherapy with one stop service: Immunological function assessment TIL analysis – Flowcytometry, Multiplex IF and Cytex Animal models – Syngeneic and humanized models Immune profiling by NGS – Single Cell RNAseq, Mutation burden and TCR/BCR repertoire Clinical biomarker services – CAP certification and GCP compliance

Resource Type: Brochure
Resource Topic: Antibodies, Autoimmune and Inflammatory Diseases, Biomarkers, Cell-based Assays, Cells and Protein Science, Hit-to-Lead, Immunology, in vivo Pharmacology, Lead Optimization, Oncology, Phenotypic Assays, Target Identification and Validation, Target-Specific Assays, Tumor Models

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Cell Line-Derived Xenograft (CDX) Tumor Models

A large collection of cell line-derived xenograft (CDX) tumor models 215 validated models, SOC data available World leading imaging based orthotopic/metastatic CDX platform 28 models covering 16 tumor types

Resource Type: Brochure
Resource Topic: in vivo Pharmacology, Lead Optimization, Oncology, Oncolytic Viruses, Small Molecules, Target Identification and Validation, Tumor Models

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >

Resource Type: Brochure
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Chemical Biology and Proteomics, Gene Therapies, High-throughput screening (HTS), Hit-to-Lead, Immunology, in vitro biology, in vivo Pharmacology, Lead Optimization, Oncology, Screening Libraries, Small Molecules, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation, Tumor Models

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Virology and Viral Vector Platforms

WuXi virology platforms: Immunology, Anti viral, Viral Vector, Oligo-nucleotide, Clinical and Immunology in vitro screening and profiling in vivo efficacy clinical virology Liver-specific viruses | Respiratory viruses | Herpes viruses | Other viruses

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biomarkers, Candidate Selection, CAR-T Cell, Cell-based Assays, Cells and Protein Science, in vivo Pharmacology, in vivo Toxicology, Infectious Diseases, Lead Optimization, Oncolytic Viruses, Phenotypic Assays, Safety and Early Toxicity

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WuXi AppTec in vitro Safety Pharmacology Profiling

Comprehensive in vitro Off-target Screening Services WuXi Discovery Biology provides in vitro Safety Pharmacology services to identify potential off-target liabilities. Three choices can be selected: WuXi Biology Mini Safety Panel “WuXi Mini 44” A primary safety panel, which is designed to identify compounds with the highest risk because it contains targets associated with the most …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Cell-based Assays, Lead Optimization, Safety and Early Toxicity, Target-Specific Assays

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in vitro Toxicity Services

Identify potential liability issues in early stages of drug discovery Cardiotoxicity hERG and other ion channel test Stem cell derived cardiomyocyte test on MEA General Cytotoxicity Cell Viability Assay Apoptosis Assay CellTox ™ Green Cytotoxicity Assay ApoTox Glo ™ Triplex Assay Mitochondrial ToxicityMitochondrial Membrane Potential Assay Mitochondrial Reactive Oxygen Species (ROS) Assay Oxygen Consumption Assay: …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Cell-based Assays, Hit-to-Lead, in vitro biology, Lead Optimization, Safety and Early Toxicity

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