DEL Empowers Discovery of Peptide Drugs

Despite the resurgence of interest in peptide therapeutics for historically “undruggable” targets, de novo discovery of peptide ligands remains a challenge.  Unlike traditional technologies, DNA-encoded libraries (DELs) predominantly employ unnatural amino acids, and the resulting cyclic peptide-like molecules which are generated display a wider range of chemical space and smaller ring sizes with improved physicochemical properties.

At the TIDES USA 2024 Conference, WuXi AppTec presented a poster showcasing the effectiveness of DELs for the discovery of macrocyclic peptides and the identification of tumor cell-specific peptide ligands as potential targeting moieties to deliver oligonucleotides.

TIDES USA Poster_DEL Empowers Discovery of Peptide Drugs

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