PROTEIN SCIENCES IN DRUG DISCOVERY 2022
Meet us at Booth 9 to learn more about our Protein Sciences Platform.
The RNA-guided dsDNA endonuclease Cas9 plays a crucial role in defending bacteria against phageinfection and has great potential to be harnessed for therapeutic gene editing. The suitability of Cas9 orthologs for therapeutic applications depends on factors such their size, activity, specificity and PAM [Charpentier et al. 2013]. During his talk , Dr. Thomas Meins will discuss techniques used to optimize the production of engineered Cas9 orthologues to provide insights into the molecular basis of the modified nuclease specificity and activity by biophysics, X-ray crystallography and cryogenic electron microscopy.
Contact us to schedule a meeting with our Team
|Production of Cas9 orthologs for functional and structural studies|
Dr. Thomas Meins | Nov.2 12:25 PM
Session - High-throughput approaches for protein expression
|Dr Thomas Meins, Head of Protein Production, WuXi AppTec|
Dr Thomas Waldmann, Head of Customer Relations, WuXi AppTec
Shaymas Hussain, Business Development Manager, WuXi AppTec